Endocrine Abstracts

Introduction: Acquired PTH Resistance (Acquired Pseudohypoparathyroidism) appears to be an extremely rare disease.Case Report: A 19-year old man with history of brain medulloblastoma treated by surgery, radiotherapy and chemotherapy 9 years earlier was admitted to hospital in 2019 due to new-onset hypocalcemia. Patient presented with muscle cramps in legs, a tingling sensation in hands and feet, numbness around the mouth, and memory disturbances. Previou...

Introduction: Co-morbidity of DM t 2 and insulinoma is extremely rare. There are only some case reports of diagnosing insulinoma but they concern patients already diagnosed with DM t. 2. We present patient diagnosed at the same time with DM t. 2 and insulinoma.Case report: A 69-year-old female patient was admitted to hospital because of high blood pressure. Since 2 years she reported attacks of weakness, tachycardia and sweating within the day, usually s...

Introduction: Generously supported by IPSEN)-->ACTH-secreting pituitary adenomas are the most common cause of endogenous hypercortisolemia in children after 10 years of age. In spite of this pediatric Cushing’s disease (pCD) is a rare medical condition. Transsphenoidal surgery (TSS) remains the treatment of choice but – according to literature date – results of such a procedure could be worse comparatively to adult pop...

Introduction: Cushing’s disease (CD) leads to glucose homeostasis alterations, obesity, unfavorable changes in body composition and cardiovascular complications.Aim of study: i) Prospective evaluation of the frequency of pre-diabetes and diabetes. ii) Assessment of insulin resistance (IR) indices in CD. iii) Analysis of the influence of family history of type 2 diabetes (T2D) on the anthropometry in CD.Methods: The study group...

Introduction: Cortisol excess in Cushing’s disease (CD) leads to glucose homeostasis alterations and increased cardiovascular risk.Aim of the study: i) To assess the reversibility of glucose homeostasis alterations and dynamics of inflammatory and coagulation parameters after the successful transsphenoidal surgery (TSS) for CD. ii) Analysis of the early improvement in insulin resistance (IR) indices following TSS.Methods: The ...

Background: Craniopharyngiomas may lead to pituitary insufficiency and neurological symptoms. However the rate of the tumor growth and the time of developing hypopituitarism are difficult to predict.Case report: A 68-year-old male of short stature (height 148 cm) was admitted to the area hospital due to loss of consciousness. The acute coronary syndrome and stroke had been excluded but laboratory tests showed hyponatremia of 106 mmol/l. Hormone measureme...

Introduction: Effective surgical treatment of Cushing’s disease (CD) is associated with a rapid decrease in the serum cortisol concentration, which requires the introduction of the hydrocortisone replacement treatment. However, the time of restoration of adrenal function is difficult to predict. The aim of the study was to evaluate the dynamics of serum cortisol concentrations after successful transsphenoidal surgery and to determine the time to restore the function of th...

Background: Cortisol excess in Cushing’s disease (CD) leads to metabolic complications, thromboembolic events, and increased cardiovascular risk. The aim of this study was to assess the reversibility of glucose homeostasis alterations and dynamics of inflammatory and coagulation parameters following the successful transsphenoidal surgery.Methods: The group consisted of 14 patients with CD (11 females; age: 41.5±14.5) operated on according to th...

Primary aldosteronism (PHA) is one of the most common cause of secondary hypertension. It can possibly concern over 10% of hypertensive patients, but often is being under-recognised. The basic tool of case PHA detection is aldosterone to renin ratio (ARR). Appropriate cutoff value of ARR is still under discussion.We review occurrence of CT/MRI detectable adrenal gland laesions according to assigned ARR cutoff value. Retrospective data from 833 consecutiv...

Di George syndrome is, in 93% of cases, the result of spontaneous mutations within the chromosome 22. Environmental factors may affect its occurrence. Phenotypic characteristics of Di George syndrome in children of alcohol-abusing or treated with izotretionin mothers were described. The case of a baby with Di George sndrome born to a woman with symptomatic hyperparathyroidism during her pregnancy is presented.Case report: A 30-year-old woman at 27 weeks ...